I've run several tires on the two big adventure bikes I've had. The 2004 BMW 1150 GS Adventure ended up wearing TKC80's all the time, Commuting mostly with weekend riding. 200,000 miles when I sold the bike.
I would usually get between 8,000 and 10,000 miles on tires. The front would cup but still have knobs but really cupped so I'd replace the set.
They are my go to tire for all around travel.
I ran the pressure at 42psi rear, 36psi front. I do the same with my 2010 KTM 990 Adventure R.
I don't pack really heavy, though I did travel very heavy back when I had to travel for work. The big work computer plus office clothes added a good bit.
The 990R does around 8,000 or so on the TKC80's but that is likely due to so much desert slab between me and where I am going to ride.
I did this little sheet back with the BMW.
My numbers were a bit more pessimistic,
8,000 miles on a rear TKC80, 2004 BMW 1150 GS Adventure:
Front:
These Scorpions were good road tires. 11,400 miles to showing peeling rubber down the center.
On the KTM 990R, I got a bit more than 9,000 miles on the Pirelli Scorpion MT90AT tires. I really like them for roads, and they work in deep sand and the mountains of Colorado.
My current TKC80's have around 4,000 miles which is terrible for me, but the bulk of the mileage is from running at high interstate speeds through epic desert heat. it was 116°F in Needles when I went through in September.
Pirelli Scorpion with 9,194 miles:
TKC80 with 3,848 miles:
Rear:
I have some Motoz tires to try, but I think I'll opt for a knobby version for the front over the more Scorpion looking tire I have.
But, I may not. I'll maybe mount them upland give them a try out at the dry lake bed and the deep sand out that way.